A novel superovulation method for cattle is user-friendly and reduces stress in cattle

Updated:September 15, 2017 (Friday)

-A single administration of hormone can induce multiple ovulation in cattle using aluminum hydroxide gel-

A research group organized with NARO Institute of Livestock and Grassland Science, Kyoritsu Seiyaku Corp., Gifu Prefectural Livestock Research Institute, Fukuoka Prefecture Agriculture and Forestry Experiment Station, National Livestock Breeding Center, and Fukui Prefecture Livestock Experiment Station can developed a novel method for superovulation of cattle by a single subcutaneous administration of follicle stimulating hormone (FSH) using aluminum hydroxide gel. In cooperation with Kyoritsu Seiyaku Corp., the product is now commercially available.


To collect many in vivo embryos for embryo transfer, cattle are treated with hormones. In the conventional superovulation procedure, a follicle stimulating hormone (FSH) is administered twice a day in step down resume for 3 to 5 days. This method is not only labor intensive but also stress cattle.

The research group headed by NARO has revealed that aluminum hydroxide gel adsorbs FSH efficiently and gradually releases it to blood circulation by substitution with body fluid components such as serum albumin. In addition, a labor-saving superovulation method by a single subcutaneous administration of FSH using this gel was developed.

In this novel method, with a single administration of FSH subcutaneously to the neck of a cow (30 AU for beef cattle and 40 AU for dairy cattle), it is possible to obtain comparable embryos to the conventional administration method which requires multiple treatments.

A sustained release agent of FSH using this aluminum hydroxide gel was formulated and is now commercially available as "Antrin R10 ・ AlR" from Kyoritsu Pharmaceutical since February 2017.

For Inquiry

Dr. Shigeru SHIOYA
Director-General, Institute of Livestock and Grassland Science, NARO

Animal Feeding Unit, Division of Animal Feeding and Management Research, NILGS

Dr. Hiromi KIMOTO
Communications Planner, NILGS