Immunosuppressive acidic protein (IAP) levels in the sera of a murine mastitis model increased, and suppurative lesions appeared. Cyclophosphamide-treated mice exhibited a shift from a suppurative lesion to a severe necrotic lesion. The results suggest that the B-lymphocytes in the mammary immune system effectively reduce the occurrence of staphylococcal necrotic mastitis.
(Lab. of Chronic Disease of Pathology, Department of Physiology and Pathology)
Reference:
Shibahara, T. and Nakamura, K.: 1999. Pathology of Acute Necrotizing Mastitis Caused by Staphylococcus aureus in a Dairy Cow. Jap. Agric. Res. Q., 33:139-142 (1999)
