The inbred strain KK is one of the most suitable polygenic mouse models for non-insulin dependent diabetes mellitus with moderate obesity. To identify the gene or genes responsible for the diseases, a QTL mapping study was carried out. We identified two QTLs for body weight and obesity on chromosomes 4 and 6.
(Lab. of Model Animals, Department of Immunology)
References:
- Suto, J., et al. :1998. Genetics of Obesity in KK Mouse and Effects of Ay Allele on Quantitative Regulation. Mamm. Genome 9 : 506-510.
- Suto, J., et al. :1998. Genetic Analysis of Non-insulin-dependent Diabetes Mellitus in KK and KK-Ay Mice. Eur. J. Endocrinol. 139 : 654-661.
- Suto, J., et al. :1999. Quantitative Trait Loci that Regulate Plasma Lipid Concentration in Hereditary Obese KK and KK-Ay Mice. Biochim. Biophys. Acta 1453 : 385-395.
