National Institute of Animal Health (NIAH)

Topics in Animal Health Research 2004

10. A nucleotide sequence analysis of a streptomycin-sulfonamide resistance plasmid, pMS260, from Actinobacillus pleuropneumoniae


A complete nucleotide sequence of an Actinobacillus pleuropneumoniae streptomycin-sulfonamide plasmid, pMS260 (8124-bp), has been determined. An analysis of the sequence revealed that pMS260 belongs to the IncQ1-γ subgroup. A 17-bp nucleotide sequence, which has the potential to acquire a gene for chloramphenicol resistance by homologous recombination, was found between the sulfonamide- and streptomycin-resistance genes of pMS260. pMS260 may therefore become a three drug (streptomycin-sulfonamide-chloramphenicol) resistance plasmid.
(Clinical Bacteriology Section, Kyushu Research Station, TEL +81-99-268-2078)


Ito et al. (2004) Plasmid 51:41-47.