National Institute of Animal Health (NIAH)

Topics in Animal Health Research 2008

24. Identification of the cell surface markers that correlate with the efficacy of cell-mediated immunity to influenza virus infections


  Cytotoxic T cells elicited by infection or vaccination play a major role in the cell-mediated immunity to viral infections. In the case of influenza virus infections, the recall efficacy and longevity of cytotoxic T cells are closely related to the expression of activation markers, such as CD27 and CD43.
(Research Team for Advanced Biologicals, TEL +81-29-838-7708)


  • Hikono, H., et al. (2006) Immunol. Rev. 211: 119-132.  
  • Hikono, H., et al. (2007) J. Exp. Med. 204: 1625-1636.
  • Hikono, H., et al. (2008) JARQ 42: 245-250.