National Institute of Animal Health (NIAH)

Topics in Animal Health Research 2011

26. Genetic diversity of group A rotaviruses associated with repeated outbreaks of diarrhoea on a farrow-to-finish farm


 Group A rotavirus (RVA) is one of the most common causes of diarrhoea in suckling pigs. Although a number of G and P genotypes have been identified in porcine RVAs, few attempts have been made to study the molecular epidemiology of these viruses associated with diarrhoeal outbreaks on a farm over an extended period of time. We investigated the molecular characteristics of RVAs that caused 4 outbreaks of diarrhoea in suckling pigs on a farrow-to-finish farm over the course of a year. G and P genotyping of the RVAs detected at each outbreak demonstrated the following genetic diversity: G9P[23] was detected at the first outbreak, G9P[13]/[22] and G9P[23] at the second, G3P[7] at the third, and G9P[23], G5P[13]/[22], and P[7] combined with an untypeable G genotype at the fourth. Sequence analysis of the detected RVAs revealed that such genetic diversity could have resulted not only from the introduction of new RVAs but also from gene reassortment among RVAs within the farm. Furthermore, the RVA carrying the untypeable G genotype was a novel porcine RVA bearing a new G26 genotype, as confirmed by the Rotavirus Classification Working Group.
(Viral Disease and Epidemiology Research Division)


Miyazaki A. et al (2011) Vet. Res. 42:112 (DOI: 10.1186/1297-9716-42-112)