Endogenous endotoxin from the rumen of cattle fed with a concentrated ration could easily induce focal necrotic lesions in the liver of cattle by intra- venous administration. One cattle died 10 hours after administration of endotoxin. Its acid phosphatase (Ap) activity of liver macrophages decreased remarkablely from 6 hours. This decrease was not recognized in survival cattle. Therefore, Ap activity of liver macrophages might be one of criterions for the prognosis of endotoxin administration.
(Second Lab. of Pathology, Third Research Division)
