National Institute of Animal Health (NIAH)

Topics in Animal Health Research 2009

02. Development of anti-prion protein monoclonal antibodies and a single-chain fragment variable derivative


  The novel anti-prion protein (PrP) monoclonal antibodies T1 and T2 can be used to detect abnormal PrPs. T2 is used in the screening test kit for bovine spongiform encephalopathy and in the diagnostic confirmation test. The single-chain fragment variable form of T2 induced a clear inhibitory effect on abnormal PrP accumulaton, thereby suggesting that it could be a useful research tool for immunotherapy of prion diseases.
(Research Team for Bacterial/Parasitic Diseases/Research Center for Prion Diseases, TEL +81-29-838-7708)


Shimizu, Y. et al. (2010) Microbiol. Immunol. 54 (2):112-121.