Pigs were orally administered the pyrazinecarboxamide derivative T-1105 followed by infection with the foot-and-mouth disease (FMD) virus O/JPN/2000 strain. The pigs did not show any clinical signs and did not excrete virus in their nasal discharge. Some of the pigs treated in the same manner with the porcinophilic FMD virus O/Taiwan/97 strain developed vesicular lesion only at the virus inoculation sites. In addition, extremely low levels of virus were excreted in their saliva. These results suggest that the derivative T-1105 is a useful tool for control measures when FMD occurs in an FMD-free country where vaccination is not practiced.
(Research Team for Exotic Diseases, TEL +81-29-838-7708)
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