National Institute of Animal Health (NIAH)

Topics in Animal Health Research 2013

03. Gnotobiotic pig as a useful model for studying the pathogenesis of porcine teschovirus in pigs


A central nervous system (CNS) disorder, characterised by non-suppurative encephalomyelitis with neurological signs, was induced experimentally in gnotobiotic pigs by intravenous and oral or intranasal inoculation of the porcine teschovirus (PTV) Toyama 2002 strain isolated from breeding pigs in Japan. The importance of the development of viraemia was confirmed in the passage of the PTV to the CNS for neural infection in pigs. Pigs with enteroviral encephalomyelitis, brought on naturally or experimentally, generally exhibit a similar distribution of the CNS lesions, which mainly affect the brainstem, cerebellum, spinal cord, and spinal ganglion, except for Teschen disease, which additionally affects the cerebrum. The characteristic neurological sign of flaccid paralysis of the hind limbs and the histological distribution of the CNS lesions may be important findings for differential diagnosis of PTV encephalomyelitis from other non-suppurative encephalomyelitis in pigs
(Viral Disease and Epidemiology Research Division)


Yamada M. et al (2013) J Comp. Pathol. 150(2-3): 276-286