National Institute of Animal Health (NIAH)

Topics in Animal Health Research 2014

15. Dose-dependent responses of pigs infected with the foot-and-mouth disease virus O/JPN/2010 by intranasal and intraoral routes

Japanese

Foot-and-mouth disease (FMDV) infection was successfully induced in pigs by intraoral inoculation of both 106 and 103 50% tissue culture infectious dose (TCID50) of the FMDV O/JPN/2010 isolated from the 2010 epidemic in Japan. Using intranasal inoculation, infection was induced in pigs with 106 TCID50 of the isolate; however, it was not successfully induced with 103 TCID50 of the isolate. In the pigs inoculated with 106 TCID50 of the isolate, viruses and viral RNAs were obtained earlier from the pigs inoculated by the intraoral route than from those inoculated by the intranasal route. These results support the theory that primary infection of a pig herd is more likely to occur by ingestion than by inhalation and that the oral cavity is likely a major entry route for FMDV in naturally exposed pigs.
(Exotic Diseases Research Division)

References:

Fukai K. et al (2015) Arch. Virol. 160(1):129–139

Centers・Institutes