National Institute of Animal Health (NIAH)

Topics in Animal Health Research 1994

01. The preparation of synthetic peptide antiserum for immunochemical diagnosis of prion diseases


Immune serum was raised in rabbit to the peptide, representing amino acid sequence 2l3-226 of mouse prion protein (PrP) and synthesized using a multiple antigenic peptide (MAP) system. Ab.213-226 reacted strongly with PrPsc of sheep, Syrian hamster and mouse. Furthermore, it could be useful in the immune diagnosis of BSE as well as scrapie.
(Third Lab.Virology, Second Research Division)