主要成果
(参考URL)
2) 味を感知する受容体のセンサー領域の立体構造を初めて解明 (外部リンク:岡山大学)
原著論文
1.Nuemket N, Yasui N, Kusakabe Y, Nomura Y, Atsumi N, Akiyama S, Nango E, Kato Y, Kaneko MK, Takagi J, Hosotani M, Yamashita A.Structural basis for perception of diverse chemical substances by T1r taste receptors. Nat Commun. (2017) 8:15530.
2.Kakutani Y, Narumi T, Kobayakawa T, Kawai T, Kusakabe Y, Kunieda S, Wada Y. Taste of breath: the temporal order of taste and smell synchronized with breathing as a determinant for taste and olfactory integration. (2017 Sci Rep. 2017 Aug 21;7(1):8922.
3.Kusakabe Y, Shindo Y, Kawai T, Takahashi Y, Kobori M, Inoue H, Saito I. "Sex-Based Differences in Smgc Expression in the Submandibular Gland of C57BL/6 Mice." Pathobiology (2016) 83, 287-294.
4.Nango E, Akiyama S, Maki-Yonekura S, Ashikawa Y, Kusakabe Y, Krayukhina E, Maruno T, Uchiyama S, Nuemket N, Yonekura K, Shimizu M, Atsumi N, Yasui N, Hikima T, Yamamoto M, Kobayashi Y, Yamashita A* "Taste substance binding elicits conformational change of taste receptor T1r heterodimer extracellular domains" Sci. Rep. (2016) 6, 25745.2
5.Shimizu M, Goto M, Kawai T, Yamashita A, Kusakabe Y. "Distinct human and mouse membrane trafficking systems for sweet taste 1 receptors T1r2 and T1r3" PLOS ONE (2014) 9, e100425.
6.Miura H, Kusakabe Y, Hashido K, Hino A, Ooki M, Harada S. "The glossopharyngeal nerve controls epithelial expression of Sprr2a and Krt13 around taste buds in the circumvallate papilla" Neurosci. Lett. (2014) 580, 147-152.
7.Sanematsu K, Kusakabe Y, Shigemura N, Hirokawa T, Nakamura S, Imoto T, Ninomiya Y. "Molecular mechanisms for sweet-suppressing effect of gymnemic acids" J. Biol. Chem. (2014) 289, 25711-25720.
成果情報
1.日下部裕子、河合崇行:味と香りのマッチングと唾液分泌の関係(2017年度)
2.河合崇行、日下部裕子:塩味を想起する香りとその記憶(2017年度)
3.日下部裕子:ヒト甘味受容体の細胞膜表面への移動の仕組み(2014年度)
4.日下部裕子:甘味受容体の構造特性を利用した、甘味物質のブレンド効果の評価 (2011年度)
特許
1.河合崇行・安室憲一・足立謙次・安部忍・濱口隆・日下部裕子 (2014). 塩味増強剤. 特開2016-106547.